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Osteoporosis Romo
Regular Exercise
Mechanism: Romo is injected subcutaneously once a month. It binds sclerostin which is a major regulator of bone modelling and thus increases formation and decreases resorption, the perfect combination. However the effect of romosozumab is attenuated after approximately a year. This is probably because the Wnt pathway which controls the reaction of bone cells to loads adapts to the new low sclerostin levels.