Simulation output for your selection:
Type 2 diabetes Romo
Mechanism: Romo is injected subcutaneously once a month. It binds sclerostin which is a major regulator of bone modelling and thus increases formation and decreases resorption, the perfect combination. However the effect of romosozumab is attenuated after approximately a year. This is probably because the Wnt pathway which controls the reaction of bone cells to loads adapts to the new low sclerostin levels.
Romo, an antibody to sclerostin, is a particularly interesting drug for people with type 2 diabetes mellitus because their sclerostin levels are high causing low formation and resorption levels.
This is indeed the best combination of treatment and exercise level for this diabetic patient. Congratulations and thank you!!!